Synthetic Studies on Several Heterocycles-NMR Spectroscopic Studies of a Few Potentially Isolable Atropisomeric Benzazepines with Speaker: Dr. Sasan Karimi, Professor, Department of Chemistry, QCC
On Thursday, Nov 7, 2024 from 05:45 PM to 10:00 PM
Location: Science Building, Room-112
This Club Event
is for Students, Alumni, Faculty and Staff
At this event, Dr. Sasan Karimi, Professor, Department of Chemistry, will focus on some of the chemistry of pyrroles, benzazepines, and quinolines.
At this event, Dr. Sasan Karimi, Professor, Department of Chemistry, will focus on some of the chemistry of pyrroles, benzazepines, and quinolines. Pyrroles have been synthesized from azido dienes, but the corresponding reactions of structurally similar nitrodienes had not been investigated until it became the focus of our study. Using this approach, we were able to synthesize several biologically active pyrroles. We have also reported a synthesis of 2-aryl-3H-1-benzazepines, in one step from 2-haloanilines and acetophenone derivatives. The impetus for that study was the possibility of new and efficient preparations of biologically active 1-benzazepines. To achieve this, we tried to functionalize the C-3 position with NBS. Instead of the expected bromobenzazpine, the reaction underwent a ring-contraction to produce quinoline. NMR experiments at room temperature show that the 3H-benzazepines undergo fast conformational exchange on the NMR time scale unless there is an alkyl substituent at C5. We have synthesized a few benzazepine derivatives that have slowed down the rate of interconversion of conformational enantiomers to allow possible separation and characterization of atroprisomers.
Registration required.
This event is sponsored by Chemistry Club, Science Research Alliance Presented by the Long Island Subsection of the American Chemical Society
Contact Name: Dr. Tirandai Hemraj-Benny
Contact Phone: (718) 281-5494
Contact Email: [email protected]
